A New Way To Address IBS

We’re developing an 8-week, clinically validated, digital program for people living with Irritable Bowel Syndrome.

Why We Need a New Approach

Irritable Bowel Syndrome (IBS) is a chronic GI condition that can cause pain and lead to anxiety, depression, and feelings of isolation. And so far, there's no one treatment approach that delivers the relief that patients want.

Patients are frustrated

71% of U.S. IBS patients have said they are dissatisfied with their care.1

There aren't many options

There are few IBS treatments and they don't address all symptoms.

Symptoms aren't under control

79% of U.S. IBS patients feel they have either no control or only partial control of their symptoms.2

1Drossman DA et al. J Clin Gastroenterol. 2009 July ; 43(6): 541–550
2 IBS Global Impact Report (2018)

Parallel Clinical Trial

The Parallel program was tested in the world’s largest (n=558) randomized, controlled trial of Cognitive Behavioral Therapy for IBS (the “ACTIB” Trial)3. The outcomes were dramatic and potentially game-changing for patients. Starting at just 3 months, patients experienced significant and clinically meaningful reduction in the severity of their IBS. At 12 months:


66% of patients reported significant and clinically meaningful reduction in the severity of their IBS .


On average, reduction in IBS severity was twice that of patients receiving medical care as usual.

3Everett et al. Gut. 2019 Sep;68(9):1613-1623.

How Does Parallel Work?

The Brain-Gut Connection

Science has revealed that your brain and your gut are in constant back-and-forth communication. In fact, they’re so connected that scientists even call the gut the “second brain.”

Cognitive Behavioral Therapy (CBT) allows us to influence the communication between your brain and gut in order to improve IBS. Dr. Emeran Mayer explains in this short video.

Emeran Mayer, MD, Phd


The Parallel Approach

For years, CBT has been used successfully to treat health issues like chronic pain4, heart disease5, and multiple sclerosis6. Parallel takes CBT online to help reduce the severity of IBS.

Personalized Feedback

As Parallel tracks your symptoms, it provides guidance based on the unique biological, environmental, and psychological aspects of your IBS.

Skills Training

You’ll develop new skills, build new habits, and get access to a toolkit of resources to help you live better with your IBS symptoms.

Complementary Treatment

Parallel doesn't replace your current treatment; it works in combination with any IBS medication your doctor may have prescribed.

4.Ehde et al. Am Psychologist. 2014;69(2):153.
5. Gulliksson et al. Arch intern med. 2011;171(2):134-140.
6. Phyo et al. Front neurol. 2018;9:149.

Interested in our clinical trial?

If you're a qualified healthcare professional interested in participating in a Mahana clinical trial, contact our Clinical Team.

Get in Touch

Parallel, formerly known as Regul8, originally was developed by Rona Moss-Morris Ph.D, Head of Psychology Department, King’s College London (KCL) in collaboration with Trudie Chalder, Ph.D, Professor of Cognitive Behavioural Psychotherapy and Alice Sibelli, Ph.D. at KCL and Dr. Hazel Everitt, Professor of Primary Care Research, University of Southampton. Initial clinical funding support was provided by the UK National Institute for Health Research (NIHR)